Of the LSDs, Gaucher disease (GD) has received particular attention over the past 15 years or so due to the genetic association between mutations in GBA, which encodes the defective lysosomal enzyme in GD, acid-beta-glucosidase (GCase), and Parkinson’s disease (PD) [3], although little data is available to permit delineation of the cellular and biochemical basis of this association [4]. Here, GBA1 is linked to Parkinson disease.