Rare LOF variants in ITSN1 (Cumulative Variant Frequency [CVF] = 0.012% in Iceland, CVF = 0.013% in the UK, and CVF = 0.10% in AMP-PD) were associated with a large effect on the risk of PD (OR = 7.3, 95% Confidence Interval [CI] = 3.5–15.2, P = 1.5 × 10−7, Table 1). This evidence concerns the gene ITSN1 and Parkinson disease.