To deeply investigate the regulatory mechanisms of autophagy in HCC, we conducted a comprehensive analysis of genes associated with key autophagy markers (ATG3, ATG5, ATG7, and Beclin-1), genes highly expressed in HCC, and genes linked to poor outcomes in HCC using data from The Cancer Genome Atlas (TCGA) database. The gene discussed is BECN1; the disease is hepatocellular carcinoma.