TNF and glioblastoma: To determine whether this is unique to SMC-sensitive GBM cells or whether SMC-treated microglia in these co-cultures can induce cell death of SMC-resistant GBM, RFP-tagged U87 human GBM cells expressing EGFRvIII, which are resistant to LCL161 and TNF-α treatment (Fig. 6E, Supplementary Fig. 9), were co-cultured with BV2 mouse microglia and treated with 10 μM LCL161.