ASPG and acute pancreatitis: A clue for the identification of the latter as a L-asparaginase target arises from an unexpected but intriguing observation that approximately 5-10% of aLL patients who were treated with L-asparaginase suffered from acute pancreatitis as a side-effect and that L-asparaginase caused PAR2-mediated rise in [Ca2+]i in pancreatic acinar cells, which was associated with acute pancreatitis [25].