IGFBP2 and invasive ductal breast carcinoma: examined 130 proteins as candidates and found that blood levels of insulin-like growth factor-binding proteins 2 and 3 (IGFBP2 and IGFBP3) in combination with CA19-9 significantly increased test performance for early stage invasive ductal adenocarcinoma of pancreas compared to CA19-9 alone (101).