The predominant molecular mechanism of AD is the formation of toxic amyloid-β oligomers and protein aggregates, as well as the formation of neurofibrillary tangles composed of Tau Protein Hyperphosphorylation, thereby leading to region-specific reduction of brain glucose metabolism synaptic dysfunction, and mitochondrial dysfunction.4There are 4 main stages in the development of AD, including the presymptomatic stage, the prodromal stage of mild cognitive impairment (MCI), and the clinical form of AD. This evidence concerns the gene MAPT and Alzheimer disease.