Notably, many of the human orthologues have been associated with nervous system diseases (ADAMTSL4, CCDC171, CD2D3, COL4A2, COL6A2, CSF1R, CLU, DPP6, FCN1, HBA1, HBB1, ITIH2, IRS2, JPH, MRVI1 PRDX2, SLC25A20, SYN2, ZNF367) (S1 Table). The gene discussed is COL6A2; the disease is nervous system disorder.