IRS2 and nervous system disorder: Notably, many of the human orthologues have been associated with nervous system diseases (ADAMTSL4, CCDC171, CD2D3, COL4A2, COL6A2, CSF1R, CLU, DPP6, FCN1, HBA1, HBB1, ITIH2, IRS2, JPH, MRVI1 PRDX2, SLC25A20, SYN2, ZNF367) (S1 Table).