After intravenous infection of immunocompromised BALB/c mice, mCMV-ΔM36 was found to replicate in liver tissue, and apoptosis was detected in situ by staining of active caspase-3 in Kupffer cells, which are the liver macrophages, but most prominently also in hepatocytes, which are the liver parenchymal cells [81]. The gene discussed is CASP3; the disease is infection.