NF-κB plays an important role in CAFs, mediating the upregulation of proteases such as COX2, CXCL1, CXCL2, CYR61/CCN1, IL-1β, IL-6, and osteopontin, thus promote tumor growth, recruit macrophages, and form tumor vasculature (Erez et al., 2010). The gene discussed is SPP1; the disease is neoplasm.