CAF can inhibit neutrophil function via the SDF-1αglycolytic activation/CXCR4/IL-6 pathway, and also secrete cardiotrophin-like cytokine factor 1 (CLCF1), which mediates the tumor’s expression of CXCL6 and TGF-β, respectively, which are responsible for neutrophil recruitment and polarization toward N2 (Figure 1). Here, CLCF1 is linked to neoplasm.