FUBP1 and adenocarcinoma: To investigate the pathological effects of FUBP1 methylation in vivo, a genetic knockin mouse model carrying a homozygous Fubp1 R354/R356/R358K mutant (Fubp13K) was generated (Supplemental Figure 5, A and B), and then crossed with the transgenic adenocarcinoma mouse prostate (TRAMP) model (46, 47).