PDK1 and prostate cancer: To investigate the clinical relevance of the BRD4-PRMT5-FUBP1-PDK1/SLC7A11 axis in prostate cancer, a tissue microarray composed of 107 paired prostate cancer and adjacent non-cancerous tissue samples from patients receiving prostatectomy was created for IHC assay of PRMT5, FUBP1, methylated FUBP1, PDK1, and SLC7A11 (Figure 7) (7).