To investigate the clinical relevance of the BRD4-PRMT5-FUBP1-PDK1/SLC7A11 axis in prostate cancer, a tissue microarray composed of 107 paired prostate cancer and adjacent non-cancerous tissue samples from patients receiving prostatectomy was created for IHC assay of PRMT5, FUBP1, methylated FUBP1, PDK1, and SLC7A11 (Figure 7) (7). Here, PDK1 is linked to Familial prostate cancer.