Major common downregulated pathways that were enriched in both the DIO versus control and DIO versus DIO Nox2-KO mice included the cardiac muscle contraction pathway (hsa04260), the dilated cardiomyopathy pathway (hsa05414), and the hypertrophic cardiomyopathy pathway (hsa05410) (Supplemental Figure 8, E and F). Here, CYBB is linked to hypertrophic cardiomyopathy.