APOE may be associated with corneal dystrophies that involve visually significant lipid deposition into the cornea, such as Schnyder corneal dystrophy,23 as well as corneal dystrophies involving amyloid deposition.24 While APOE is associated with an increased risk of systemic herpes infections25 it is unclear if this risk extends to herpetic keratitis and its sequelae, although there is a suggestion of increased APOE2 variant in this population.26,27 When used topically in an animal model, APOE peptide mimetic appeared to exhibit some antiviral properties.28 This evidence concerns the gene APOE and corneal dystrophy.