Overexpression of ERBB2 occurred in approximately 15%-30% of breast cancers and was strongly associated with recurrence, the aggressiveness of tumors, overall survival, and a poor prognosis.4 The association between choline metabolism and this histologic marker is not entirely understood, even though there are reports on the transfection of human breast tissue cells with the HER2 gene, which has been known to cause an increase in phosphocholine.5 The gene discussed is ERBB2; the disease is breast cancer.