CHKA and breast cancer: Few studies have evaluated the association of HER2-negative breast cancer phenotypes with cell membrane metabolism via choline kinase cellular reprogramming.3-4 Gene expression based on the intrinsic classification of breast cancer can be categorized into 4 subtypes: luminal A, luminal B, typical breast-like HER2, and a basal-like subtype.3 Changes in the expression of various genes have resulted in significantly different clinical outcomes due to alterations in the cellular pathways and other mutational profiles that reflect the tumor microenvironment.