Antigen-specific CD8+ Tn cells from Vegfb WT or -cKO OT-1 mice were activated by OVA257–264 peptide followed by lentivirus-mediated Senp2 overexpression, and then these OT-1 T cells were adaptively transferred to recipient mice with MC38-OVA tumor cells inoculated (Figure 8I). Here, SENP2 is linked to neoplasm.