These findings of the MNK/eIF4E axis regulating β-catenin activation via ATX/LPA/LPA1 signaling are supported by a previous study in chronic myeloid leukemia granulocyte-macrophage progenitors where MNK kinase–dependent eIF4E phosphorylation at Ser209 was shown to be specifically linked to nuclear translocation and activation of β-catenin (15). This evidence concerns the gene ENPP2 and chronic myelogenous leukemia, BCR-ABL1 positive.