For example, increased levels of phosphorylated cAMP response element-binding protein (pCREB) and its downstream effector, the orphan nuclear receptor subfamily 4 group A member 2 (NR4A2) (22–24), have been identified in neurons of normal-appearing grey matter (NAGM) and MS lesions (25), providing molecular evidence for chronic hyperexcitability in MS (26). The gene discussed is NR4A2; the disease is myeloid sarcoma.