ERVW-1 and dengue disease: Although targeted degradation of E could also affect the assembly of new virions, this mode of action has not been reported for classical inhibitors of dengue E or other viral envelope proteins.[36] In addition, since dengue E has been thought to be co‐translationally inserted through the ER membrane to the ER lumen, this raises questions as to how and where it is accessible and susceptible to the E3 CRL4CRBN ubiquitin ligase and proteasome.