Being cognizant of these findings, we endeavored to investigate the conformational properties of the aggregates formed by three mutant forms of tau 2N4R (the longest isoform): (a) tau A152T, which was recently identified as a risk factor for FTD and AD (Coppola et al., 2012), (b) tau P301L, and (c) tau R406W, along with the native form. Here, MAPT is linked to frontotemporal dementia.