In a rat model of cerebral ischemia/reperfusion injury, Na+/K+-ATPase activity was found to be reduced in the model group compared to the sham-operated group, and Na+/K+-ATPase activity exhibited a significant positive correlation with the bcl-2/bax ratio and a significant negative correlation with the score of neurological deficits as well as the percentage of apoptotic neurons (apoptotic index) (Huang et al., 2015). This evidence concerns the gene BAX and Cerebral ischemia.