BAX and brain ischemia: In a rat model of cerebral ischemia/reperfusion injury, Na+/K+-ATPase activity was found to be reduced in the model group compared to the sham-operated group, and Na+/K+-ATPase activity exhibited a significant positive correlation with the bcl-2/bax ratio and a significant negative correlation with the score of neurological deficits as well as the percentage of apoptotic neurons (apoptotic index) (Huang et al., 2015).