The explanatory variables are given in Table 1: hormonal therapy- a factor at two levels, baseline age of the individuals, menopausal status—pre and post, tumor size (in mm), tumor grade—at three ordered levels I<II<III, number of positive nodes, progesterone and estrogen receptor (in fmol) (Sauerbrei et al., 2000). This evidence concerns the gene ESR1 and neoplasm.