Weight loss has been shown to reduce pro-inflammatory markers present in the chronic low-grade inflammatory state associated with obesity, including CRP, IL-6 and TNF-a (Christiansenet al., 2010;Marfellaet al., 2004;Moelleret al., 2016) and may thereby help manage LC symptoms. The gene discussed is TNF; the disease is obesity due to melanocortin 4 receptor deficiency.