ACE = angiotensin-converting enzyme; ARA = angiotensin receptor antagonist; AKI = acute kidney injury; ASA = American Society of Anesthesiologists; BNP = brain natriuretic peptide; IQR = interquartile range; Hs-TnI = high-sensitivity troponin I; MAC = monitored anesthesia care. The gene discussed is NPPB; the disease is acute kidney injury.