A four-drug induction with prednisone, vincristine, daunorubicin, and Pegylated Asparaginase (PEG)-asparaginase was initially started according to the AIEOP-BFM ALL 2017 protocol (EudraCT 2016–001935–12 and NCT03643276). The gene discussed is ASPG; the disease is acute lymphoblastic leukemia.