For instance, dual-programmable semiconducting polymer (SP)-based nanoPROTACs can generate singlet oxygen upon ultrasound excitation, generate hydroxyl free radicals for ferroptosis by tumor microenvironment H2O2 stimulation, and release a Nicotinamide phosphoribosyl transferase PROTAC degrader which suppresses immunity evasion of tumor cells (Wang F. et al., 2024). The gene discussed is NAMPT; the disease is neoplasm.