CASP3 and neoplasm: Other in vivo photoactivatable constructs such as Nano-PROTAC (NPRO) targeting the Src homology 2 domain-containing phosphatase 2 (SHP2) are linked via caspase 3 cleavable signal to a photosensitizer which under 660 nm photoirradiation generates O2 causing tumor apoptosis and overexpression of caspase-3 that subsequently cleaves the segment releasing the active catalytic PROTAC (Zhang C. et al., 2022).