Yu et al. (67) examined the HCC tissues of patients who experienced recurrence after primary HCC resection and sequential sorafenib treatment and found an inverse expression between CYP1A2 and NF-κB p65 in the sorafenib-naïve primary HCC compared with its paired sorafenib-experienced recurrence. Here, CYP1A2 is linked to hepatocellular carcinoma.