Additionally, Gal-3 derived from mesenchymal stem cells has been shown to clear aberrant forms of tau and reduce hyperphosphorylation of tau both in vitro and in vivo, as well as ameliorate deficits in spatial learning and memory, confirming the potential therapeutic role of Gal-3 in AD pathology and associated memory impairment (51). This evidence concerns the gene MAPT and Alzheimer disease.