AKT and ERK are the central functional target kinases in PI3K/AKT and RAF/MEK/ERK signaling pathways, whose activation is closely related to CLL cell survival and anti-apoptosis (Kawauchi et al., 2002; Ringshausen et al., 2002; Chen et al., 2016; Chen et al., 2019). Here, AKT1 is linked to B-cell chronic lymphocytic leukemia.