We found that APG-115 can effectively inhibit cell viability and induce cell apoptosis in CLL (Figures 2A–C), supported by the progressive cleavage of PARP and activation of caspase-3 (Figures 2D, E), which is consistent with the observation in DLBCL, AML, and ALL (Luo et al., 2020; Zhai et al., 2023). Here, CASP3 is linked to acute lymphoblastic leukemia.