Meanwhile, the expressions of PARP, Caspase-3, and Caspase-9 decreased, suggesting that apoptosis could be achieved through Caspase-9 and Caspase-3 cleavages inducing PARP cleavage, which confirmed that baicalein enhanced almonertinib-induced apoptosis in almonertinib-resistant NSCLC cells. Here, CASP3 is linked to non-small cell lung carcinoma.