INS and gestational diabetes: On the one hand, 5-HT2Bagonists have been shown to promote insulin secretion, partly regulatedby an increase in intracellular Ca2+ and enhanced mitochondrialactivity.47 Additionally, increased expressionof 5-HT2B in mouse islets during pregnancy has been shown to enhanceβ cell proliferation while its pharmacological blockade impairedglucose tolerance, suggesting that this receptor could be a favorabletarget for treating gestational diabetes and T2D.48