Huang et al. reported that psilocybinreduced weight gain in rats fed a cafeteria diet but had no effecton weight loss at the given doses.44 Likewise,Fadahunsi et al. found that psilocybin had no impact on body weightor food intake in various conditions, including lean mice, DIO mice,and genetic models of obesity (ob/ob mice and melanocortin-receptor 4 knockout mice).40 In contrast, our study is the first to demonstrate thatMEAI significantly induced weight loss and beneficial changes in bodycomposition in DIO mice without altering food intake. The gene discussed is MC4R; the disease is obesity due to melanocortin 4 receptor deficiency.