GRM2 and nervous system disorder: The metabotropic glutamate receptor 2 (mGluR2) has emerged as a potentialtherapeutic target for the treatment of various neurological diseases, promptingsubstantial interest in the development of mGluR2-targeted drug candidates.As part of our medicinal chemistry program, we synthesized a series of isoindolonederivatives and assessed their potential as mGluR2 positive allostericmodulators (PAMs).