YWHAH and Alzheimer disease: According to a study published in 2020 by Gu et al., people with AD may have impaired antiapoptotic function in their frontal cortex due to downregulation of 14-3-3γ (YWHAG) and 14-3-3η (YWHAH), which could accelerate the death of neural cells and exacerbate the pathogenesis of AD (Gu et al., 2020).