Because the metabolic syndrome is accompanied by dental/periodontal damage (Timonen et al., 2010) coupled with an increase in the circulating levels of FGF21 (Sawangpanyangkura et al., 2022), which can be potentially cariogenic (Soberg et al., 2017), and MUHNW subjects express IR, inflammation, and later progression to dysmetabolism like in the metabolic syndrome, it is reasonable to expect disorders of their dental health as an early event. This evidence concerns the gene FGF21 and metabolic syndrome.