Based on the updated International Union of Immunological Societies PID classification, some other mutated genes were classified, such as zinc finger protein 341 (ZNF341), serine peptidase inhibitor kazal type 5 (SPINK5), tyrosine kinase 2 (TYK2), IL‐6 signal transducer (IL6ST), and so on.138. The gene discussed is SPINK5; the disease is pelvic inflammatory disease.