Furthermore, we transfected NLRP3 cDNA to induce BC cells to overexpress NLRP3 protein, which not only further increased the levels of IL-1β, IL-18, and TNF-α but also promoted BC cell malignant behaviors and related protein expression, indicating a pivotal role of NLRP3 in the inflammatory microenvironment. This evidence concerns the gene NLRP3 and breast cancer.