Stable activity of NLRP3 is essential for maintaining cellular homeostasis and a healthy body, while abnormal activation of NLRP3 may result in inflammation-related and neoplastic diseases [31] as well as accelerate the progression of malignant tumors [32, 33]; besides, NLRP3 gene mutations have been correlated to dominantly inherited autoinflammatory diseases like cryopyrin-associated periodic syndrome [34]. Here, NLRP3 is linked to cancer.