A previous pan-cancer study has analyzed NLRP3-inflammasome-related genes in 24 human cancers and has revealed that 15 of 24 cancer types have differential expression of NLRP3-inflammasome-related genes in tumor samples vs. normal ones, and the NLRP3 gene was generally hypomethylated in 10 of 15 cancer types [35]. Here, NLRP3 is linked to neoplasm.