NLRP3 and neoplasm: To confirm the role of NLRP3 on the effects of cryptotanshinone in 5,637 cells, we first pretreated tumor cells with LPS, then transfected them with an NLRP3-overexpression plasmid (pcDNA3.1-NLRP3) and afterward treated them with 4 μM cryptotanshinone.