SACK1A and metastatic malignant neoplasm in the lymph nodes: Next, we proceeded to explore the relationship between the expression of RHOV, ANLN, PTTG1, DLGAP5, and FAM83A with pathological stage and lymph node metastasis, and the results showed that the transcriptional expression of the five prognostic features progressively increased with the stage (Figures 12A, B).