PTTG1 and cancer: PTTG1 is highly expressed and associated with poor prognosis in a variety of cancers, including lung adenocarcinoma, hepatocellular carcinoma, breast cancer, and glioma, and its expression is positively correlated with tumor oncogenicity and significantly affects the ability of tumors to proliferate, migrate, and invade by upregulating cellular markers of epithelial-mesenchymal transition (EMT) and transcriptional factors that induce a malignant phenotype in tumors (26–29).