(61), we found that PTTG1 was highly expressed in CD4_CTLA4 and CD8_LAYN cell subsets, which may suggest that high PTTG1 expression is highly correlated with immunosuppression of tumor-infiltrating Tregs and depleted CD8+ T cell formation (Supplementary Figures 3G-I). The gene discussed is PTTG1; the disease is neoplasm.