Given the potential problems that acne can cause for patients and the possible effects of using the medication for acne treatment on lipid profiles and inflammatory markers, including leptin in patients' bodies, as well as the concerns and questions many patients have about the drug's effects on their weight, we aimed to investigate changes in BMI and markers of metabolic syndrome in patients with severe acne vulgaris undergoing isotretinoin treatment at the Dermatology Clinic both before starting treatment and 3 months after treatment. Here, LEP is linked to acne.