In the SELF-ADH group, no incipient enamel caries were observed at the 3- or 6-month follow-up, while in the RB group, there was one cavitated enamel caries lesion at the 3- or 6-month follow-up; however, the difference between the two groups was not significant (P = 0.890). This evidence concerns the gene AVP and enamel caries.