Viral infection experiments involving RIG-I interference and TRIM5 overexpression in cells revealed that the expression of RIG-I (P < 0.01), MAVS (P < 0.05), IRF3 (P < 0.05), IRF7 (P < 0.01), TAK1 (P < 0.05), IFN-α (P < 0.01), IFN-β (P < 0.01), IL-1β (P < 0.05), IL-6 (P < 0.01), and IL-18 (P < 0.05) was decreased compared to that in the control group but was greater than that in the pEGFP-N1 + shRIG-I group (Figure 6E and F). Here, TRIM5 is linked to viral infectious disease.