Conversely, viral infection experiments in cells with impeded expression of TRIM5 revealed that RIG-I expression at 12 (P < 0.05) and 24 hpi (P < 0.01); MAVS expression at 6, 12, and 24 hpi (P < 0.01); IRF3 expression at 6 (P < 0.01), 12 (P < 0.05), and 24 hpi (P < 0.01); IRF7 expression at 6 (P < 0.05), 12, and 24 hpi (P < 0.01); and TAK1 expression at 6, 12 (P < 0.01), and 24 hpi (P < 0.05) were significantly lower than those in the control (Figure 5F–J). Here, TRIM5 is linked to viral infectious disease.