TRIM5 and viral infectious disease: Moreover, viral infection experiments in cells with impeded expression of TRIM5 revealed that the expression of IFN-α at 12 (P < 0.05) and 24 hpi (P < 0.01); the expression of IFN-β at 12 and 24 hpi (P < 0.01); the expression of IL-1β at 6, 12 (P < 0.01), and 24 hpi (P < 0.05); the expression of IL-6 at 6 (P < 0.05), 12 (P < 0.01), and 24 hpi (P < 0.05); and the expression of IL-18 at 6 (P < 0.05), 12, and 24 hpi (P < 0.01) significantly decreased (Figure 4F–J).