Viral infection experiments in cells with impeded TRIM5 expression showed that the mRNA expression of the SVA VP3 gene was significantly increased from 24 to 48 hpi compared to that in the control (P < 0.01) (Figure 3H), and the expression of the SVA VP2 protein was significantly upregulated at 24 hpi (P < 0.01) (Figure 3I and J). The gene discussed is TRIM5; the disease is viral infectious disease.