The analyzed specimen featured a hair follicle surrounded by an inflammatory infiltrate, based on the cluster and subcluster signature genes from acne scRNA-seq dataset (Figure S1A), defining and identifying the location of spots of eight distinct cell populations including TREM2 macrophages, other macrophages, KRT5 and KRT16 keratinocytes, fibroblasts, endothelial cells, B cells, and other cell types (Fig. 4A). The gene discussed is KRT5; the disease is acne.