Several of these, including PIK3CG (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit γ), PACSIN2 (protein kinase C and casein kinase substrate in neurons protein 2), and PRKCB (protein kinase C β type), were also associated with longitudinal cognitive performance and plasma biomarkers of AD pathology (amyloid beta (Aβ)42/40, phosphorylated tau (pTau)-181), neuronal injury (neurofilament light chain (NfL)) or reactive astrogliosis (glial fibrillary acidic protein (GFAP)). The gene discussed is NEFL; the disease is Alzheimer disease.