Among the male samples, 29 lncRNAs out of the 180 were found to be significantly dysregulated in AD, with PCBP3-AS1 emerging as the most upregulated (3.15 ± 1.49) candidate, whereas ENSG00000289510 was found to be the most downregulated (− 4.77 ± 2.02). Here, PCBP3 is linked to Alzheimer disease.