The top RBPs ELAVL4 (GSE184942: − 1.13 ± 0.44; GSE173955: − 1.64 ± 0.25; AD model: 3.22 ± 0.87), LSM11 (GSE173955: − 0.91 ± 0.16; GSE184942: − 0.77 ± 0.38; AD cell model: − 0.7976 ± 0.2128), and MSI2 (GSE173955: 0.36 ± 0.12; GSE184942: 0.79 ± 0.31; AD model: 10.31 ± 2.81) and miRNAs miR-16-5p (GSE63501: 0.95 ± 0.39; AD cell model: 0.79 ± 0.13) and miR-7-5p (GSE63501: − 1.1 ± 0.34; AD cell model: − 0.55 ± 0.07) were experimentally validated as well. This evidence concerns the gene MSI2 and Alzheimer disease.