These models use kidney-specific inactivation of RCC tumour suppressor-encoding genes such as Vhl and Setd2, with biallelic deletion of a 40-kb region of mouse chromosome 4q, which is syntenic to a region of human chromosome 9p21 (4q9p21−) that is frequently lost in human metastatic kidney cancers. This evidence concerns the gene VHL and renal cell carcinoma.