Enhanced expression of BCAT1 disrupts BCAA metabolism and contributes to liver disease, inflammatory disease, insulin resistance, Alzheimer’s disease, and tumor progression.14,28,29 BCAT1 catalyzes the reversible transamination of BCAAs to BCKAs, accompanied by the amination of α-KG to glutamate, and these metabolites are involved in multiple cellular processes. Here, BCAT1 is linked to early-onset autosomal dominant Alzheimer disease.