EGFR and non-small cell lung carcinoma: Compelling evidence has shown that increasing glycolysis contributes to EGFR TKI resistance and chemoresistance in NSCLC.24–26 To explore whether enhanced glucose metabolism was involved in resistance to EGFR TKIs, we first assessed glycolytic activity in TKI-resistant cells and NCI-H1975 cells using a Seahorse XF analyzer.