Moreover, α-KG impacts gene expression and cellular stemness by activating the Jumonji-C (JmjC) family of lysine demethylases (KDMs) (JmjC-KDMs) and ten-eleven translocation (TET) enzymes which mediate histone- and DNA demethylation, respectively.17 Additionally, glutamate dehydrogenase 1 (GLUD1) mediated α-KG production contributes to triggering epithelial-mesenchymal transition in docetaxel- or gefitinib-resistant lung cancer.18 Nonetheless, the precise mechanisms linking α-KG to drug resistance remain unclear. This evidence concerns the gene GLUD1 and lung cancer.