NLRP3 and rheumatoid arthritis: In summary, we have firstly identified caspase-11-mediated inflammasome activation in macrophages possibility induces RA, A. actinomycetemcomitans activates caspase-11-mediated NLRP3 inflammasome, and discovered inhibitor for caspase-11-mediated inflammasome activation potentiate suppression of RA.