In addition, since previous reports demonstrated that NLRP3 inflammasome activation exacerbates arthritis.20,84 and IL-1β production contributes to the activation of immune cells, chondrocytes, osteoclasts, and induction of fibroblast proliferation,65 our findings must have some relevance to the enhancement of arthritis severity. The gene discussed is NLRP3; the disease is Arthritis.