IL1B and infection: 55 Therefore, to investigate whether β2 integrin is necessary for inflammasome activation during infection with A. actinomycetemcomitans, we focused on β2 integrin in macrophage-1 antigen (MAC-1, CR3, integrin αMβ2) and it can also serve as a receptor for diverse microbial ligands.56,57 The caspase-1 activation, IL-1β and IL-6 release were reduced in BMDMs administered an antibody against CD11b, but not control IgG or an inhibitory antibody against CD18 during infection with A. actinomycetemcomitans ATCC29522 (Fig. 6a–c).