Additional AGS-associated missense mutations in IFIH1 (p.Arg337Gly, p.Arg779Cys, p.Gly495Arg, p.Asp393Val, p.Arg720Gln, p.Arg779His, p.Ala452Thr, and p.Leu372Phe) are all positioned close to the RNA-binding or ATP-binding sites in the MDA5 helicase domain (Oda et al., 2014). The gene discussed is IFIH1; the disease is Aicardi-Goutieres syndrome.