Surprisingly, not all associated GWAS loci of FLI were associated with obesity-related lipid traits, but replicated risk loci of the FLI, FTO and ZPR1, also had associations with elevated ALT and AST levels in a recent GWAS on liver enzymes [41], further strengthening its relationship with hepatic steatosis. The gene discussed is ZPR1; the disease is obesity due to melanocortin 4 receptor deficiency.