Genetic variants of rs56094641 located in FTO have been replicated in a large GWAS of unexplained chronic ALT elevations as proxy of MAFLD with histological and radiological validations [12], and are highly associated with adipose tissues, body size (BMI, body fat rate, and waist circumference) energy intake, and T2DM [37,42,43]. Here, FTO is linked to type 2 diabetes mellitus.