Similar patterns were observed in the CSF of patients with leucine-rich glioma inactivated 1 (LGI1) encephalitis, but not in N-methyl-D-aspartate receptor (NMDAR) encephalitis, where many mAbs showed few SHM or were even unmutated (Kornau et al., 2020; Kreye et al., 2016; Sun et al., 2020; Theorell et al., 2024). This evidence concerns the gene LGI1 and viral encephalitis.