To characterize the intrathecal antibody repertoire and to investigate CASPR2 autoantibody effects at the monoclonal level, CSF cells from two CASPR2 encephalitis patients were isolated via flow cytometry following our established protocols (Kornau et al., 2020; Kreye et al., 2020, 2016). The gene discussed is CNTNAP2; the disease is viral encephalitis.