Recent findings indicate that Hsp90 acts as a nucleating site for the assembly of the epichaperomes,30, 31, 32, 33 networks of stable, survival-facilitating multiprotein complexes characterized by tumor-specific traits of physical and functional integration absent in normal cells.5, 34, 35, 36 Furthermore, the assembly of these complex structures is modulated by the presence of PTMs, some of which only emerge in pathologic conditions that specifically underlie cancer or neurodegenerative diseases.30, 37. The gene discussed is HSP90AB1; the disease is cancer.