HLTF and cancer: Consistent with its genome maintenance functions, HLTF is a tumor suppressor.60 Knockout of HLTF in mice causes genome instability and susceptibility to intestinal carcinogenesis.61 Moreover, HLTF silencing is frequently observed in colorectal and gastric cancers62,63 and is associated with poor prognosis.64 Understanding HLTF’s functions may therefore reveal vulnerabilities associated with HLTF-deficient cancers.